Early Indium-111 antimyosin scintigraphy for assessment of regional wall motion asynergy on discharge after myocardial infarction
Identifieur interne : 000444 ( Main/Exploration ); précédent : 000443; suivant : 000445Early Indium-111 antimyosin scintigraphy for assessment of regional wall motion asynergy on discharge after myocardial infarction
Auteurs : RBID : ISTEX:10554_1990_Article_BF01797841.pdfEnglish descriptors
Abstract
To assess the relation between early Indium-111 monoclonal antimyosin antibody scintigraphy and degree of regional asynergy on discharge, 38 patients with a first acute myocardial infarct were studied (18 anterior, 20 inferoposterior infarctions). In 21 patients thrombolytic therapy was administered. On the first day of myocardial infarction, 80 MBq Indium-111 Antimyosin was injected. Planar images, anterior, lateral and left anterior oblique, were made 24 hours later. Localized myocardial uptake was present in 37/38 patients, and was evaluated for Count Density Index (count density of infarct zone/left lung count density) in the left anterior oblique images, which displayed the infarct zone well. Regional asynergy on discharge was evaluated by cross-sectional echocardiography and defined mild (hypokinesia) or severe (akinesia or dyskinesia). Count density index was significantly lower in 15 patients with mild asynergy, compared with 22 patients with severe asynergy (1.61±0.25 vs. 2.42±0.40, p<0.001). This difference was present in both patient groups treated with or without thrombolysis. We conclude that early count density index, reflecting the amount of local necrosis, is highly correlated to the ultimate degree of wall motion impairment.
DOI: 10.1007/BF01797841
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Visser</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea><wicri:noRegion>Amsterdam</wicri:noRegion></affiliation></author><author wicri:is="90%"><name>Eric van Royen</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nuclear Medicine, Academic Medical Center, Amsterdam</wicri:regionArea><wicri:noRegion>Amsterdam</wicri:noRegion></affiliation></author><author wicri:is="90%"><name>Ben J. Delemarre</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea><wicri:noRegion>Amsterdam</wicri:noRegion></affiliation></author><author wicri:is="90%"><name>Hans Bot</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea><wicri:noRegion>Amsterdam</wicri:noRegion></affiliation></author><author wicri:is="90%"><name>Arend J. Dunning</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea><wicri:noRegion>Amsterdam</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:10554_1990_Article_BF01797841.pdf</idno><date when="1990">1990</date><idno type="doi">10.1007/BF01797841</idno><idno type="wicri:Area/Main/Corpus">000B08</idno><idno type="wicri:Area/Main/Curation">000B08</idno><idno type="wicri:Area/Main/Exploration">000444</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Indium-111 Antimyosin</term><term>Myocardial infarction</term><term>Wall motion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">To assess the relation between early Indium-111 monoclonal antimyosin antibody scintigraphy and degree of regional asynergy on discharge, 38 patients with a first acute myocardial infarct were studied (18 anterior, 20 inferoposterior infarctions). In 21 patients thrombolytic therapy was administered. On the first day of myocardial infarction, 80 MBq Indium-111 Antimyosin was injected. Planar images, anterior, lateral and left anterior oblique, were made 24 hours later. Localized myocardial uptake was present in 37/38 patients, and was evaluated for Count Density Index (count density of infarct zone/left lung count density) in the left anterior oblique images, which displayed the infarct zone well. Regional asynergy on discharge was evaluated by cross-sectional echocardiography and defined mild (hypokinesia) or severe (akinesia or dyskinesia). Count density index was significantly lower in 15 patients with mild asynergy, compared with 22 patients with severe asynergy (1.61±0.25 vs. 2.42±0.40, p<0.001). This difference was present in both patient groups treated with or without thrombolysis. We conclude that early count density index, reflecting the amount of local necrosis, is highly correlated to the ultimate degree of wall motion impairment.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="c1ddf9c481911fa49a7a0f2ce03c4852dbfecfd7"><titleInfo lang="eng"><title>Early Indium-111 antimyosin scintigraphy for assessment of regional wall motion asynergy on discharge after myocardial infarction</title></titleInfo><name type="personal"><namePart type="given">Bob</namePart><namePart type="family">van Vlies</namePart><role><roleTerm type="text">Afdeling Cardiologie</roleTerm></role><affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></name><name type="personal"><namePart type="given">Jim</namePart><namePart type="family">Baas</namePart><affiliation>Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands</affiliation></name><name type="personal"><namePart type="given">Cees A.</namePart><namePart type="family">Visser</namePart><affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></name><name type="personal"><namePart type="given">Eric</namePart><namePart type="family">van Royen</namePart><affiliation>Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands</affiliation></name><name type="personal"><namePart type="given">Ben J.</namePart><namePart type="family">Delemarre</namePart><affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></name><name type="personal"><namePart type="given">Hans</namePart><namePart type="family">Bot</namePart><affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></name><name type="personal"><namePart type="given">Arend J.</namePart><namePart type="family">Dunning</namePart><affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</affiliation></name><typeOfResource>text</typeOfResource><genre>Original Paper</genre><originInfo><publisher>Kluwer Academic Publishers, Dordrecht</publisher><dateValid encoding="w3cdtf">2005-05-14</dateValid><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">To assess the relation between early Indium-111 monoclonal antimyosin antibody scintigraphy and degree of regional asynergy on discharge, 38 patients with a first acute myocardial infarct were studied (18 anterior, 20 inferoposterior infarctions). In 21 patients thrombolytic therapy was administered. On the first day of myocardial infarction, 80 MBq Indium-111 Antimyosin was injected. Planar images, anterior, lateral and left anterior oblique, were made 24 hours later. Localized myocardial uptake was present in 37/38 patients, and was evaluated for Count Density Index (count density of infarct zone/left lung count density) in the left anterior oblique images, which displayed the infarct zone well. Regional asynergy on discharge was evaluated by cross-sectional echocardiography and defined mild (hypokinesia) or severe (akinesia or dyskinesia). Count density index was significantly lower in 15 patients with mild asynergy, compared with 22 patients with severe asynergy (1.61±0.25 vs. 2.42±0.40, p<0.001). This difference was present in both patient groups treated with or without thrombolysis. We conclude that early count density index, reflecting the amount of local necrosis, is highly correlated to the ultimate degree of wall motion impairment.</abstract><subject lang="eng"><genre>Key words</genre><topic>Indium-111 Antimyosin</topic><topic>myocardial infarction</topic><topic>wall motion</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Int J Cardiac Imag</title></titleInfo><titleInfo><title>The International Journal of Cardiac Imaging</title><partNumber>Year: 1990</partNumber><partNumber>Volume: 5</partNumber><partNumber>Number: 4</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1990-12-01</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Cardiology</topic></subject><identifier type="issn">0167-9899</identifier><identifier type="issn">Electronic: 1573-0743</identifier><identifier type="matrixNumber">10554</identifier><identifier type="local">IssueArticleCount: 7</identifier><recordInfo><recordOrigin>Kluwer Academic Publishers, 1990</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF01797841</identifier><identifier type="matrixNumber">Art3</identifier><identifier type="local">BF01797841</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>241</start><end>248</end></extent></part><recordInfo><recordOrigin>Kluwer Academic Publishers, 1990</recordOrigin><recordIdentifier>10554_1990_Article_BF01797841.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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